Pro-Inflammatory Signaling Upregulates a Neurotoxic Conotoxin-Like Protein Encrypted Within Human Endogenous Retrovirus-K

Pro-Inflammatory Signaling Upregulates a Neurotoxic Conotoxin-Like Protein Encrypted Within Human Endogenous Retrovirus-K

Motor neuron degeneration and spinal cord demyelination are hallmark pathological events in Amyotrophic Lateral Sclerosis (ALS). Endogenous retrovirus-K (ERVK) expression has an established association with ALS neuropathology, with murine modeling pointing to a role for the ERVK envelope (<i>e...

Full description

Bibliographic Details
Main Authors: Domenico Di Curzio, Mamneet Gurm, Matthew Turnbull, Marie-Josée Nadeau, Breanna Meek, Julia D. Rempel, Samuel Fineblit, Michael Jonasson, Sherry Hebert, Jennifer Ferguson-Parry, Renée N. Douville
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cells
Subjects:
endogenous retrovirus
amyotrophic lateral sclerosis
conotoxin
HIV Tat
NF-κB
necroptosis
Online Access:https://www.mdpi.com/2073-4409/9/7/1584

Internet

https://www.mdpi.com/2073-4409/9/7/1584

Similar Items