Characterization of the peripheral FAAH inhibitor, URB937, in animal models of acute and chronic migraine

Characterization of the peripheral FAAH inhibitor, URB937, in animal models of acute and chronic migraine

Inhibiting the activity of fatty-acid amide hydrolase (FAAH), the enzyme that deactivates the endocannabinoid anandamide, enhances anandamide-mediated signaling and holds promise as a molecular target for the treatment of human pathologies such as anxiety and pain. We have previously shown that the...

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Bibliographic Details
Main Authors: Rosaria Greco, Chiara Demartini, Annamaria Zanaboni, Ilenia Casini, Roberto De Icco, Angelo Reggiani, Alessandra Misto, Daniele Piomelli, Cristina Tassorelli
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Neurobiology of Disease
Subjects:
NTG
Migraine
Trigeminal hyperalgesia
URB937
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120304320

Internet

http://www.sciencedirect.com/science/article/pii/S0969996120304320

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