Design, Sustainable Synthesis and Biological Evaluation of a Novel Dual α2A/5-HT7 Receptor Antagonist with Antidepressant-Like Properties

Design, Sustainable Synthesis and Biological Evaluation of a Novel Dual α2A/5-HT7 Receptor Antagonist with Antidepressant-Like Properties

The complex pathophysiology of depression, together with the limits of currently available antidepressants, has resulted in the continuous quest for alternative therapeutic strategies. Numerous findings suggest that pharmacological blockade of α<sub>2</sub>-adrenoceptor might be benefici...

Full description

Bibliographic Details
Main Authors: Vittorio Canale, Magdalena Kotańska, Anna Dziubina, Matylda Stefaniak, Agata Siwek, Gabriela Starowicz, Krzysztof Marciniec, Patryk Kasza, Grzegorz Satała, Beata Duszyńska, Xavier Bantreil, Frédéric Lamaty, Marek Bednarski, Jacek Sapa, Paweł Zajdel
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
α<sub>2</sub> adrenoceptor antagonist
5-HT<sub>7</sub> receptor antagonist
medicinal mechanochemistry
depression
forced swim test
Online Access:https://www.mdpi.com/1420-3049/26/13/3828

Internet

https://www.mdpi.com/1420-3049/26/13/3828

Similar Items