Design, Sustainable Synthesis and Biological Evaluation of a Novel Dual α2A/5-HT7 Receptor Antagonist with Antidepressant-Like Properties
The complex pathophysiology of depression, together with the limits of currently available antidepressants, has resulted in the continuous quest for alternative therapeutic strategies. Numerous findings suggest that pharmacological blockade of α<sub>2</sub>-adrenoceptor might be benefici...
Main Authors: | Vittorio Canale, Magdalena Kotańska, Anna Dziubina, Matylda Stefaniak, Agata Siwek, Gabriela Starowicz, Krzysztof Marciniec, Patryk Kasza, Grzegorz Satała, Beata Duszyńska, Xavier Bantreil, Frédéric Lamaty, Marek Bednarski, Jacek Sapa, Paweł Zajdel |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-06-01
|
Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/26/13/3828 |
Similar Items
-
<i>N</i>-Skatyltryptamines—Dual 5-HT<sub>6</sub>R/D<sub>2</sub>R Ligands with Antipsychotic and Procognitive Potential
by: Agata Hogendorf, et al.
Published: (2021-07-01) -
The Multi-Targeting Ligand ST-2223 with Histamine H<sub>3</sub>Receptor and Dopamine D<sub>2</sub>/D<sub>3</sub> Receptor Antagonist Properties Mitigates Autism-Like Repetitive Behaviors and BrainOxidative Stress in Mice
by: Nermin Eissa, et al.
Published: (2021-02-01) -
Blockade of Serotonin 5-HT<sub>6</sub> Receptor Constitutive Activity Alleviates Cognitive Deficits in a Preclinical Model of Neurofibromatosis Type 1
by: Emilie Doucet, et al.
Published: (2021-09-01) -
Adenosine Receptors as Neuroinflammation Modulators: Role of A<sub>1</sub> Agonists and A<sub>2A</sub> Antagonists
by: Aleix Martí Navia, et al.
Published: (2020-07-01) -
β<sub>2</sub>-adrenoceptor blockage induces G<sub>1</sub>/S phase arrest and apoptosis in pancreatic cancer cells via Ras/Akt/NFκB pathway
by: Zhang Dong, et al.
Published: (2011-11-01)