Akt-activated endothelium promotes ovarian cancer proliferation through notch activation

Akt-activated endothelium promotes ovarian cancer proliferation through notch activation

Abstract Background One main challenge in ovarian cancer rests on the presence of a relapse and an important metastatic disease, despite extensive surgical debulking and chemotherapy. The difficulty in containing metastatic cancer is partly due to the heterotypic interaction of tumor and its microen...

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Bibliographic Details
Main Authors: Jessica Hoarau-Véchot, Cyril Touboul, Najeeb Halabi, Morgane Blot-Dupin, Raphael Lis, Charbel Abi Khalil, Shahin Rafii, Arash Rafii, Jennifer Pasquier
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Translational Medicine
Subjects:
Ovarian cancer
Tumor microenvironment
Cell–cell interactions
Endothelial cells
Online Access:http://link.springer.com/article/10.1186/s12967-019-1942-z

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http://link.springer.com/article/10.1186/s12967-019-1942-z

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