Neodymium-140 DOTA-LM3: Evaluation of an In Vivo Generator for PET with a Non-Internalizing Vector

Neodymium-140 DOTA-LM3: Evaluation of an In Vivo Generator for PET with a Non-Internalizing Vector

140Nd (t1/2 = 3.4 days), owing to its short-lived positron emitting daughter 140Pr (t1/2 = 3.4 min), has promise as an in vivo generator for positron emission tomography (PET). However, the electron capture decay of 140Nd is chemically disruptive to macrocycle-based radiolabeling, meaning that an in...

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Bibliographic Details
Main Authors: Gregory W. Severin, Lotte K. Kristensen, Carsten H. Nielsen, Jesper Fonslet, Andreas I. Jensen, Anders F. Frellsen, K. M. Jensen, Dennis R. Elema, Helmut Maecke, Andreas Kjær, Karl Johnston, Ulli Köster
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Medicine
Subjects:
in vivo generator
140Nd
140Pr
internalization
positron emission tomography
DOTA-LM3
Online Access:http://journal.frontiersin.org/article/10.3389/fmed.2017.00098/full

Internet

http://journal.frontiersin.org/article/10.3389/fmed.2017.00098/full

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