Synergistic Activity of Niclosamide in Combination With Colistin Against Colistin-Susceptible and Colistin-Resistant Acinetobacter baumannii and Klebsiella pneumoniae

Synergistic Activity of Niclosamide in Combination With Colistin Against Colistin-Susceptible and Colistin-Resistant Acinetobacter baumannii and Klebsiella pneumoniae

Colistin is among the few antibiotics effective against multidrug-resistant Acinetobacter baumannii and Klebsiella pneumoniae clinical isolates. However, in the last few years, colistin-resistant A. baumannii and K. pneumoniae strains have emerged. Therefore, combination therapies, between colistin...

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Bibliographic Details
Main Authors: Rafael Ayerbe-Algaba, María Luisa Gil-Marqués, Manuel Enrique Jiménez-Mejías, Viviana Sánchez-Encinales, Raquel Parra-Millán, María Eugenia Pachón-Ibáñez, Jerónimo Pachón, Younes Smani
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
repurposing drug
niclosamide
colistin
synergistic effect
Acinetobacter baumannii
Klebsiella pneumoniae
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00348/full

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https://www.frontiersin.org/article/10.3389/fcimb.2018.00348/full

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