P150glued-associated disorders are caused by activation of intrinsic apoptotic pathway.

P150glued-associated disorders are caused by activation of intrinsic apoptotic pathway.

Mutations in p150glued cause hereditary motor neuropathy with vocal cord paralysis (HMN7B) and Perry syndrome (PS). Here we show that both overexpression of p150glued mutants and knockdown of endogenous p150glued induce apoptosis. Overexpression of a p150glued plasmid containing either a HMN7B or PS...

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Bibliographic Details
Main Authors: Kei-Ichi Ishikawa, Shinji Saiki, Norihiko Furuya, Daisuke Yamada, Yoko Imamichi, Yuanzhe Li, Sumihiro Kawajiri, Hironori Sasaki, Masato Koike, Yoshio Tsuboi, Nobutaka Hattori
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3983229?pdf=render

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http://europepmc.org/articles/PMC3983229?pdf=render

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