Combining imaging- and gene-based hypoxia biomarkers in cervical cancer improves prediction of chemoradiotherapy failure independent of intratumour heterogeneity

Combining imaging- and gene-based hypoxia biomarkers in cervical cancer improves prediction of chemoradiotherapy failure independent of intratumour heterogeneity

Background: Emerging biomarkers from medical imaging or molecular characterization of tumour biopsies open up for combining the two and exploiting their synergy in treatment planning of cancer patients. We generated a paired data set of imaging- and gene-based hypoxia biomarkers in cervical cancer,...

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Bibliographic Details
Main Authors: Christina S. Fjeldbo, Tord Hompland, Tiril Hillestad, Eva-Katrine Aarnes, Clara-Cecilie Günther, Gunnar B. Kristensen, Eirik Malinen, Heidi Lyng
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:EBioMedicine
Subjects:
Prognostic biomarker
Medical imaging
Gene expression signature
Hypoxia
Intratumour heterogeneity
Cervical cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420302164

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http://www.sciencedirect.com/science/article/pii/S2352396420302164

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