Heterokaryon-based reprogramming of human B lymphocytes for pluripotency requires Oct4 but not Sox2.
Differentiated cells can be reprogrammed through the formation of heterokaryons and hybrid cells when fused with embryonic stem (ES) cells. Here, we provide evidence that conversion of human B-lymphocytes towards a multipotent state is initiated much more rapidly than previously thought, occurring i...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-09-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC2527997?pdf=render |