Targeting mitochondrial cell death pathway to overcome drug resistance with a newly developed iron chelate.

Targeting mitochondrial cell death pathway to overcome drug resistance with a newly developed iron chelate.

BACKGROUND: Multi drug resistance (MDR) or cross-resistance to multiple classes of chemotherapeutic agents is a major obstacle to successful application of chemotherapy and a basic problem in cancer biology. The multidrug resistance gene, MDR1, and its gene product P-glycoprotein (P-gp) are an impor...

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Bibliographic Details
Main Authors: Avishek Ganguly, Soumya Basu, Paramita Chakraborty, Shilpak Chatterjee, Avijit Sarkar, Mitali Chatterjee, Soumitra Kumar Choudhuri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2889820?pdf=render

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http://europepmc.org/articles/PMC2889820?pdf=render

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