Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype

Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype

Summary: Tumor and stromal interactions consist of reciprocal signaling through cytokines, growth factors, direct cell-cell interactions, and extracellular vesicles (EVs). Small EVs (≤200 nm) have been considered critical messengers of cellular communication during tumor development. Here, we demons...

Full description

Bibliographic Details
Main Authors: Shaolin Ma, Michael H. McGuire, Lingegowda S. Mangala, Sanghoon Lee, Elaine Stur, Wen Hu, Emine Bayraktar, Alejandro Villar-Prados, Cristina Ivan, Sherry Y. Wu, Akira Yokoi, Santosh K. Dasari, Nicholas B. Jennings, Jinsong Liu, Gabriel Lopez-Berestein, Prahlad Ram, Anil K. Sood
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Cell Reports
Subjects:
small EVs
p53
CAFs
HSP90
Nrf2
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721000395

Internet

http://www.sciencedirect.com/science/article/pii/S2211124721000395

Similar Items