The HSF1–PARP13–PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis

The HSF1–PARP13–PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis

PARP1 recruitment to DNA lesions is critical for DNA damage repair but how DNA damage induces PARP1 redistribution is largely unknown. Here, the authors provide evidence that PARP1 redistribution and DNA repair in tumor cells depend on the formation of a HSF1–PARP13–PARP1 complex.

Bibliographic Details
Main Authors: Mitsuaki Fujimoto, Ryosuke Takii, Eiichi Takaki, Arpit Katiyar, Ryuichiro Nakato, Katsuhiko Shirahige, Akira Nakai
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01807-7

Internet

https://doi.org/10.1038/s41467-017-01807-7

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