CHEK1 and circCHEK1_246aa evoke chromosomal instability and induce bone lesion formation in multiple myeloma

CHEK1 and circCHEK1_246aa evoke chromosomal instability and induce bone lesion formation in multiple myeloma

Abstract Background Multiple myeloma (MM) is still incurable and characterized by clonal expansion of plasma cells in the bone marrow (BM). Therefore, effective therapeutic interventions must target both myeloma cells and the BM niche. Methods Cell proliferation, drug resistance, and chromosomal ins...

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Bibliographic Details
Main Authors: Chunyan Gu, Wang Wang, Xiaozhu Tang, Tingting Xu, Yanxin Zhang, Mengjie Guo, Rongfang Wei, Yajun Wang, Artur Jurczyszyn, Siegfried Janz, Meral Beksac, Fenghuang Zhan, Anja Seckinger, Dirk Hose, Jingxuan Pan, Ye Yang
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Molecular Cancer
Subjects:
Multiple myeloma
CHEK1
circCHEK1_246aa
Proliferation
Drug resistance
Chromosomal instability
Online Access:https://doi.org/10.1186/s12943-021-01380-0

Internet

https://doi.org/10.1186/s12943-021-01380-0

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