PLCε regulates prostate cancer mitochondrial oxidative metabolism and migration via upregulation of Twist1

PLCε regulates prostate cancer mitochondrial oxidative metabolism and migration via upregulation of Twist1

Abstract Background Metabolic rewiring is a common feature of many cancer types, including prostate cancer (PCa). Alterations in master genes lead to mitochondrial metabolic rewiring and provide an appealing target to inhibit cancer progression and improve survival. Phospholipase C (PLC)ε is a regul...

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Bibliographic Details
Main Authors: Jiaxin Fan, Yanru Fan, Xiao Wang, Lingfang Niu, Limei Duan, Jinxiao Yang, Luo Li, Yingying Gao, Xiaohou Wu, Chunli Luo
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
PLCε
Twist1
Prostate cancer
Mitochondrial metabolic
Migration
MAPK
Online Access:http://link.springer.com/article/10.1186/s13046-019-1323-8

Internet

http://link.springer.com/article/10.1186/s13046-019-1323-8

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