Tacrolimus Updated Guidelines through popPK Modeling: How to Benefit More from CYP3A Pre-emptive Genotyping Prior to Kidney Transplantation

Tacrolimus Updated Guidelines through popPK Modeling: How to Benefit More from CYP3A Pre-emptive Genotyping Prior to Kidney Transplantation

Tacrolimus (Tac) is a profoundly effective immunosuppressant that reduces the risk of rejection after solid organ transplantation. However, its use is hampered by its narrow therapeutic window along with its highly variable pharmacological (pharmacokinetic [PK] and pharmacodynamic [PD]) profile. Par...

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Bibliographic Details
Main Authors: Jean-Baptiste Woillard, Michel Mourad, Michael Neely, Arnaud Capron, Ron H. van Schaik, Teun van Gelder, Nuria Lloberas, Dennis A. Hesselink, Pierre Marquet, Vincent Haufroid, Laure Elens
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Pharmacology
Subjects:
tacrolimus
kidney transplantation
CYP3A
single nucleotide polymorphisms
population pharmacokinetics
dosage recommendations
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00358/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00358/full

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