Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson’s Disease
Accumulation and misfolding of the alpha-synuclein protein are core mechanisms in the pathogenesis of Parkinson’s disease. While the normal function of alpha-synuclein is mainly related to the control of vesicular neurotransmission, its pathogenic effects are linked to various cellular functions, wh...
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Online Access: | http://www.mdpi.com/2218-273X/5/4/2675 |
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doaj-3d7215ac97e745dbb88c11213dfec04a2020-11-24T22:37:14ZengMDPI AGBiomolecules2218-273X2015-10-01542675270010.3390/biom5042675biom5042675Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson’s DiseaseWojciech Bobela0Patrick Aebischer1Bernard Laurent Schneider2Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, SwitzerlandBrain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, SwitzerlandBrain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, SwitzerlandAccumulation and misfolding of the alpha-synuclein protein are core mechanisms in the pathogenesis of Parkinson’s disease. While the normal function of alpha-synuclein is mainly related to the control of vesicular neurotransmission, its pathogenic effects are linked to various cellular functions, which include mitochondrial activity, as well as proteasome and autophagic degradation of proteins. Remarkably, these functions are also affected when the renewal of macromolecules and organelles becomes impaired during the normal aging process. As aging is considered a major risk factor for Parkinson’s disease, it is critical to explore its molecular and cellular implications in the context of the alpha-synuclein pathology. Here, we discuss similarities and differences between normal brain aging and Parkinson’s disease, with a particular emphasis on the nigral dopaminergic neurons, which appear to be selectively vulnerable to the combined effects of alpha-synuclein and aging.http://www.mdpi.com/2218-273X/5/4/2675alpha-synucleinParkinson’s diseaseagingmitochondriaproteostasisnigral dopaminergic neuronsmetabolism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wojciech Bobela Patrick Aebischer Bernard Laurent Schneider |
spellingShingle |
Wojciech Bobela Patrick Aebischer Bernard Laurent Schneider Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson’s Disease Biomolecules alpha-synuclein Parkinson’s disease aging mitochondria proteostasis nigral dopaminergic neurons metabolism |
author_facet |
Wojciech Bobela Patrick Aebischer Bernard Laurent Schneider |
author_sort |
Wojciech Bobela |
title |
Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson’s Disease |
title_short |
Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson’s Disease |
title_full |
Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson’s Disease |
title_fullStr |
Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson’s Disease |
title_full_unstemmed |
Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson’s Disease |
title_sort |
αlpha-synuclein as a mediator in the interplay between aging and parkinson’s disease |
publisher |
MDPI AG |
series |
Biomolecules |
issn |
2218-273X |
publishDate |
2015-10-01 |
description |
Accumulation and misfolding of the alpha-synuclein protein are core mechanisms in the pathogenesis of Parkinson’s disease. While the normal function of alpha-synuclein is mainly related to the control of vesicular neurotransmission, its pathogenic effects are linked to various cellular functions, which include mitochondrial activity, as well as proteasome and autophagic degradation of proteins. Remarkably, these functions are also affected when the renewal of macromolecules and organelles becomes impaired during the normal aging process. As aging is considered a major risk factor for Parkinson’s disease, it is critical to explore its molecular and cellular implications in the context of the alpha-synuclein pathology. Here, we discuss similarities and differences between normal brain aging and Parkinson’s disease, with a particular emphasis on the nigral dopaminergic neurons, which appear to be selectively vulnerable to the combined effects of alpha-synuclein and aging. |
topic |
alpha-synuclein Parkinson’s disease aging mitochondria proteostasis nigral dopaminergic neurons metabolism |
url |
http://www.mdpi.com/2218-273X/5/4/2675 |
work_keys_str_mv |
AT wojciechbobela alphasynucleinasamediatorintheinterplaybetweenagingandparkinsonsdisease AT patrickaebischer alphasynucleinasamediatorintheinterplaybetweenagingandparkinsonsdisease AT bernardlaurentschneider alphasynucleinasamediatorintheinterplaybetweenagingandparkinsonsdisease |
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