Sensitivity to Sevoflurane anesthesia is decreased in mice with a congenital deletion of Guanylyl Cyclase-1 alpha

Sensitivity to Sevoflurane anesthesia is decreased in mice with a congenital deletion of Guanylyl Cyclase-1 alpha

Abstract Background Volatile anesthetics increase levels of the neurotransmitter nitric oxide (NO) and the secondary messenger molecule cyclic guanosine monophosphate (cGMP) in the brain. NO activates the enzyme guanylyl cyclase (GC) to produce cGMP. We hypothesized that the NO-GC-cGMP pathway contr...

Full description

Bibliographic Details
Main Authors: Yasuko Nagasaka, Martin Wepler, Robrecht Thoonen, Patrick Y. Sips, Kaitlin Allen, Jan A. Graw, Vincent Yao, Sara M. Burns, Stefan Muenster, Peter Brouckaert, Keith Miller, Ken Solt, Emmanuel S. Buys, Fumito Ichinose, Warren M. Zapol
Format: Article
Language:English
Published: BMC 2017-06-01
Series:BMC Anesthesiology
Subjects:
Nitric oxide
Soluble guanylyl cyclase
Knock-out mouse
Volatile anesthetics
Sevoflurane
Righting reflex
Online Access:http://link.springer.com/article/10.1186/s12871-017-0368-5

Internet

http://link.springer.com/article/10.1186/s12871-017-0368-5

Similar Items