Altered Nutrient Uptake Causes Mitochondrial Dysfunction in Senescent CD8+ EMRA T Cells During Type 2 Diabetes

Altered Nutrient Uptake Causes Mitochondrial Dysfunction in Senescent CD8+ EMRA T Cells During Type 2 Diabetes

Mitochondrial health and cellular metabolism can heavily influence the onset of senescence in T cells. CD8+ EMRA T cells exhibit mitochondrial dysfunction and alterations to oxidative phosphorylation, however, the metabolic properties of senescent CD8+ T cells from people living with type 2 diabetes...

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Bibliographic Details
Main Authors: Lauren A. Callender, Elizabeth C. Carroll, Conor Garrod-Ketchley, Johannes Schroth, Jonas Bystrom, Victoria Berryman, Melanie Pattrick, Desiree Campbell-Richards, Gillian A. Hood, Graham A. Hitman, Sarah Finer, Sian M. Henson
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Aging
Subjects:
type 2 diabetes
ageing
mitochondria
metabolism
T cell
senescence
Online Access:https://www.frontiersin.org/articles/10.3389/fragi.2021.681428/full

Internet

https://www.frontiersin.org/articles/10.3389/fragi.2021.681428/full

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