Neuronal CCL2 expression drives inflammatory monocyte infiltration into the brain during acute virus infection

Neuronal CCL2 expression drives inflammatory monocyte infiltration into the brain during acute virus infection

Abstract Background Viral encephalitis is a dangerous compromise between the need to robustly clear pathogen from the brain and the need to protect neurons from bystander injury. Theiler’s murine encephalomyelitis virus (TMEV) infection of C57Bl/6 mice is a model of viral encephalitis in which the c...

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Bibliographic Details
Main Authors: Charles L. Howe, Reghann G. LaFrance-Corey, Emma N. Goddery, Renee K. Johnson, Kanish Mirchia
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Journal of Neuroinflammation
Subjects:
Theiler’s murine encephalomyelitis virus
Inflammatory monocyte
CCL2
CCR2
Hippocampus
Encephalitis
Online Access:http://link.springer.com/article/10.1186/s12974-017-1015-2

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http://link.springer.com/article/10.1186/s12974-017-1015-2

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