Oxidized low-density lipoprotein (oxLDL) supports Mycobacterium tuberculosis survival in macrophages by inducing lysosomal dysfunction.

Type 2 diabetes mellitus (DM) is a major risk factor for developing tuberculosis (TB). TB-DM comorbidity is expected to pose a serious future health problem due to the alarming rise in global DM incidence. At present, the causal underlying mechanisms linking DM and TB remain unclear. DM is associate...

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Bibliographic Details
Main Authors: Frank Vrieling, Louis Wilson, Patrick C N Rensen, Gerhard Walzl, Tom H M Ottenhoff, Simone A Joosten
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-04-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007724