Dietary and Genetic Cholesterol Loading Rather Than Steatosis Promotes Liver Tumorigenesis and NASH-Driven HCC

Dietary and Genetic Cholesterol Loading Rather Than Steatosis Promotes Liver Tumorigenesis and NASH-Driven HCC

The association of nonalcoholic steatohepatitis (NASH) with obesity and type 2 diabetes is a major determinant factor for the continued rise of NASH-driven HCC. Unfortunately, the mechanisms underlying the progression from NASH to HCC are not well-understood. Steatosis is characterized by the accumu...

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Bibliographic Details
Main Authors: Vicent Ribas, Laura Conde de la Rosa, David Robles, Susana Núñez, Paula Segalés, Naroa Insausti-Urkia, Estel Solsona-Vilarrasa, José C. Fernández-Checa, Carmen García-Ruiz
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
cholesterol
hepatocellular carcinoma
steatosis
NASH
Online Access:https://www.mdpi.com/2072-6694/13/16/4091

Internet

https://www.mdpi.com/2072-6694/13/16/4091

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