Asymmetric Synthesis of Optically Pure Aliphatic Amines with an Engineered Robust ω-Transaminase

Asymmetric Synthesis of Optically Pure Aliphatic Amines with an Engineered Robust ω-Transaminase

The production of chiral amines by transaminase-catalyzed amination of ketones is an important application of biocatalysis in synthetic chemistry. It requires transaminases that show high enantioselectivity in asymmetric conversion of the ketone precursors. A robust derivative of ω-transaminase from...

Full description

Bibliographic Details
Main Authors: Linhan Dong, Qinglong Meng, Carlos Ramírez-Palacios, Hein J. Wijma, Siewert J. Marrink, Dick B. Janssen
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Catalysts
Subjects:
transamination
asymmetric synthesis
alkanamines
transaminase
computational modeling
Online Access:https://www.mdpi.com/2073-4344/10/11/1310

Internet

https://www.mdpi.com/2073-4344/10/11/1310

Similar Items