Fluid proteomics of CSF and serum reveal important neuroinflammatory proteins in blood–brain barrier disruption and outcome prediction following severe traumatic brain injury: a prospective, observational study

Fluid proteomics of CSF and serum reveal important neuroinflammatory proteins in blood–brain barrier disruption and outcome prediction following severe traumatic brain injury: a prospective, observational study

Abstract Background Severe traumatic brain injury (TBI) is associated with blood–brain barrier (BBB) disruption and a subsequent neuroinflammatory process. We aimed to perform a multiplex screening of brain enriched and inflammatory proteins in blood and cerebrospinal fluid (CSF) in order to study t...

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Bibliographic Details
Main Authors: Caroline Lindblad, Elisa Pin, David Just, Faiez Al Nimer, Peter Nilsson, Bo-Michael Bellander, Mikael Svensson, Fredrik Piehl, Eric Peter Thelin
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Critical Care
Subjects:
Traumatic brain injury
Protein biomarkers
Proteomics
Neuroinflammation
Blood–brain barrier
Apolipoprotein E4
Online Access:https://doi.org/10.1186/s13054-021-03503-x

Internet

https://doi.org/10.1186/s13054-021-03503-x

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