Structural determinants of microtubule minus end preference in CAMSAP CKK domains

Structural determinants of microtubule minus end preference in CAMSAP CKK domains

CKK domain containing CAMSAP/Patronins recognise and regulate microtubule (MT) minus end dynamics. Here the authors compare cryo-EM structures of MT-bound human CKK and Naegleria gruberi CKK which lacks minus-end binding preference, finding NgCKK has a different interaction with, and inability to re...

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Bibliographic Details
Main Authors: Joseph Atherton, Yanzhang Luo, Shengqi Xiang, Chao Yang, Ankit Rai, Kai Jiang, Marcel Stangier, Annapurna Vemu, Alexander D. Cook, Su Wang, Antonina Roll-Mecak, Michel O. Steinmetz, Anna Akhmanova, Marc Baldus, Carolyn A. Moores
Format: Article
Language:English
Published: Nature Publishing Group 2019-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13247-6

Internet

https://doi.org/10.1038/s41467-019-13247-6

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