ApoE4 Delays Dendritic Spine Formation during Neuron Development and Accelerates Loss of Mature Spines
The ε4 allele of the gene that encodes apolipoprotein E (APOE4) is the greatest genetic risk factor for Alzheimer's disease (AD), while APOE2 reduces AD risk, compared to APOE3. The mechanism(s) underlying the effects of APOE on AD pathology remains unclear. In vivo , dendritic spine density is...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2013-12-01
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| Series: | ASN Neuro |
| Online Access: | https://doi.org/10.1042/AN20130043 |