Maturation of the Human Immunoglobulin Heavy Chain Repertoire With Age

Maturation of the Human Immunoglobulin Heavy Chain Repertoire With Age

B cells play a central role in adaptive immune processes, mainly through the production of antibodies. The maturation of the B cell system with age is poorly studied. We extensively investigated age-related alterations of naïve and antigen-experienced immunoglobulin heavy chain (IgH) repertoires. Th...

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Bibliographic Details
Main Authors: Marie Ghraichy, Jacob D. Galson, Aleksandr Kovaltsuk, Valentin von Niederhäusern, Jana Pachlopnik Schmid, Mike Recher, Annaïse J. Jauch, Enkelejda Miho, Dominic F. Kelly, Charlotte M. Deane, Johannes Trück
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
antibody
B cells
children
heavy chain
immunoglobulin
maturation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01734/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01734/full

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