Multivariate Curve Resolution and Carbon Balance Constraint to Unravel FTIR Spectra from Fed-Batch Fermentation Samples

Multivariate Curve Resolution and Carbon Balance Constraint to Unravel FTIR Spectra from Fed-Batch Fermentation Samples

The current work investigates the capability of a tailored multivariate curve resolution–alternating least squares (MCR-ALS) algorithm to analyse glucose, phosphate, ammonium and acetate dynamics simultaneously in an E. coli BL21 fed-batch fermentation. The high-cell-density (HCDC) process is monito...

Full description

Bibliographic Details
Main Authors: Dennis Vier, Stefan Wambach, Volker Schünemann, Klaus-Uwe Gollmer
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:Bioengineering
Subjects:
multivariate curve resolution
E. coli
fed-batch
fermentation
carbon mass balance constraint
soft constraints
alternating least squares
hybrid modelling
Online Access:http://www.mdpi.com/2306-5354/4/1/9

Internet

http://www.mdpi.com/2306-5354/4/1/9

Similar Items