Whole blood profiling of leprosy type 1(reversal) reactions highlights prominence of innate immune response genes

Whole blood profiling of leprosy type 1(reversal) reactions highlights prominence of innate immune response genes

Abstract Background The major factors contributing for nerve damage and permanent disabilities in leprosy are type 1 or reversal reactions (RR) and type 2 or erythema nodosum leprosum (ENL). Gene profiling of leprosy reactions have shown that different pathways are activated during the course of rea...

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Bibliographic Details
Main Authors: Jamile Leão Rêgo, Nadja de Lima Santana, Paulo Roberto Lima Machado, Marcelo Ribeiro-Alves, Thiago Gomes de Toledo-Pinto, Léa Cristina Castellucci, Milton Ozório Moraes
Format: Article
Language:English
Published: BMC 2018-08-01
Series:BMC Infectious Diseases
Subjects:
Leprosy reactions; gene expression; profile
Parkin
Pro-inflammatory
Type-I IFN
OASL
Online Access:http://link.springer.com/article/10.1186/s12879-018-3348-6

Internet

http://link.springer.com/article/10.1186/s12879-018-3348-6

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