The Effects of Biological Sex on Sepsis Treatments in Animal Models: A Systematic Review and a Narrative Elaboration on Sex- and Gender-Dependent Differences in Sepsis

The Effects of Biological Sex on Sepsis Treatments in Animal Models: A Systematic Review and a Narrative Elaboration on Sex- and Gender-Dependent Differences in Sepsis

OBJECTIVES:. Preclinical studies provide an opportunity to evaluate the relationship between sex and sepsis, and investigate underlying mechanisms in a controlled experimental environment. The objective of our systematic review was to assess the impact of biological sex on treatment response to flui...

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Main Authors: MengQi Zhang, BSc, Joshua Montroy, MSc, Rahul Sharma, HBSc, Dean A. Fergusson, MHA, PhD, Asher A. Mendelson, MD, PhD, FRCPC, Kimberly F. Macala, MD, FRCPC, Stephane L. Bourque, PhD, Jared M. Schlechte, BSc, Mikaela K. Eng, MSc, Braedon McDonald, MD, PhD, FRCPC, Sean E. Gill, PhD, Kirsten M. Fiest, PhD, Patricia C. Liaw, MSc, PhD, Alison Fox-Robichaud, MSc, MD, FRCPC, Manoj M. Lalu, MD, PhD, FRCPC, on behalf of the Canadian Critical Care Translational Biology Group and the Sepsis Canada National Preclinical Sepsis Platform
Format: Article
Language:English
Published: Wolters Kluwer 2021-06-01
Series:Critical Care Explorations
Online Access:http://journals.lww.com/10.1097/CCE.0000000000000433

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http://journals.lww.com/10.1097/CCE.0000000000000433

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