KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice

KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice

Somatic KRAS mutations are highly prevalent in many cancers. In addition, a distinct spectrum of germline KRAS mutations causes developmental disorders called RASopathies. The mutant proteins encoded by these germline KRAS mutations are less biochemically and functionally activated than those in can...

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Bibliographic Details
Main Authors: Jasmine C. Wong, Pedro A. Perez-Mancera, Tannie Q. Huang, Jangkyung Kim, Joaquim Grego-Bessa, Maria del pilar Alzamora, Scott C. Kogan, Amnon Sharir, Susan H. Keefe, Carolina E. Morales, Denny Schanze, Pau Castel, Kentaro Hirose, Guo N. Huang, Martin Zenker, Dean Sheppard, Ophir D. Klein, David A. Tuveson, Benjamin S. Braun, Kevin Shannon
Format: Article
Language:English
Published: American Society for Clinical investigation 2020-11-01
Series:JCI Insight
Subjects:
Genetics
Online Access:https://doi.org/10.1172/jci.insight.140495

Internet

https://doi.org/10.1172/jci.insight.140495

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