CALCIUM-SENSING RECEPTORS OF HUMAN NEURAL CELLS PLAY CRUCIAL ROLES IN ALZHEIMER’S DISEASE
In aged subjects, late-onset Alzheimer’s disease (LOAD) starts in the lateral entorhinal allocortex where a failure of clearance mechanisms triggers an accumulation neurotoxic of amyloid-β42 oligomers (Aβ42-os). In neurons and astrocytes, Aβ42-os enhance the transcription of Aβ precursor protein (A...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-04-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00134/full |