Regulation of mTORC2 Signaling
Mammalian target of rapamycin (mTOR), a serine/threonine protein kinase and a master regulator of cell growth and metabolism, forms two structurally and functionally distinct complexes, mTOR complex 1 (mTORC1) and mTORC2. While mTORC1 signaling is well characterized, mTORC2 is relatively poorly unde...
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| Format: | Article |
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MDPI AG
2020-09-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/11/9/1045 |
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doaj-3d95f9a06f3d4e6fa4845f7d48a82ae82020-11-25T03:16:56ZengMDPI AGGenes2073-44252020-09-01111045104510.3390/genes11091045Regulation of mTORC2 SignalingWenxiang Fu0Michael N. Hall1Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming 650500, ChinaBiozentrum, University of Basel, CH4056 Basel, SwitzerlandMammalian target of rapamycin (mTOR), a serine/threonine protein kinase and a master regulator of cell growth and metabolism, forms two structurally and functionally distinct complexes, mTOR complex 1 (mTORC1) and mTORC2. While mTORC1 signaling is well characterized, mTORC2 is relatively poorly understood. mTORC2 appears to exist in functionally distinct pools, but few mTORC2 effectors/substrates have been identified. Here, we review recent advances in our understanding of mTORC2 signaling, with particular emphasis on factors that control mTORC2 activity.https://www.mdpi.com/2073-4425/11/9/1045mTORmTORC2 signalingAktsignaling crosstalk |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Wenxiang Fu Michael N. Hall |
| spellingShingle |
Wenxiang Fu Michael N. Hall Regulation of mTORC2 Signaling Genes mTOR mTORC2 signaling Akt signaling crosstalk |
| author_facet |
Wenxiang Fu Michael N. Hall |
| author_sort |
Wenxiang Fu |
| title |
Regulation of mTORC2 Signaling |
| title_short |
Regulation of mTORC2 Signaling |
| title_full |
Regulation of mTORC2 Signaling |
| title_fullStr |
Regulation of mTORC2 Signaling |
| title_full_unstemmed |
Regulation of mTORC2 Signaling |
| title_sort |
regulation of mtorc2 signaling |
| publisher |
MDPI AG |
| series |
Genes |
| issn |
2073-4425 |
| publishDate |
2020-09-01 |
| description |
Mammalian target of rapamycin (mTOR), a serine/threonine protein kinase and a master regulator of cell growth and metabolism, forms two structurally and functionally distinct complexes, mTOR complex 1 (mTORC1) and mTORC2. While mTORC1 signaling is well characterized, mTORC2 is relatively poorly understood. mTORC2 appears to exist in functionally distinct pools, but few mTORC2 effectors/substrates have been identified. Here, we review recent advances in our understanding of mTORC2 signaling, with particular emphasis on factors that control mTORC2 activity. |
| topic |
mTOR mTORC2 signaling Akt signaling crosstalk |
| url |
https://www.mdpi.com/2073-4425/11/9/1045 |
| work_keys_str_mv |
AT wenxiangfu regulationofmtorc2signaling AT michaelnhall regulationofmtorc2signaling |
| _version_ |
1724634078622253056 |