Experimentally guided models reveal replication principles that shape the mutation distribution of RNA viruses

Life history theory posits that the sequence and timing of events in an organism's lifespan are fine-tuned by evolution to maximize the production of viable offspring. In a virus, a life history strategy is largely manifested in its replication mode. Here, we develop a stochastic mathematical m...

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Bibliographic Details
Main Authors: Michael B Schulte, Jeremy A Draghi, Joshua B Plotkin, Raul Andino
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-01-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/03753