Experimentally guided models reveal replication principles that shape the mutation distribution of RNA viruses
Life history theory posits that the sequence and timing of events in an organism's lifespan are fine-tuned by evolution to maximize the production of viable offspring. In a virus, a life history strategy is largely manifested in its replication mode. Here, we develop a stochastic mathematical m...
Main Authors: | Michael B Schulte, Jeremy A Draghi, Joshua B Plotkin, Raul Andino |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2015-01-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/03753 |
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