IFITM3 restricts influenza A virus entry by blocking the formation of fusion pores following virus-endosome hemifusion.
Interferon-induced transmembrane proteins (IFITMs) inhibit infection of diverse enveloped viruses, including the influenza A virus (IAV) which is thought to enter from late endosomes. Recent evidence suggests that IFITMs block virus hemifusion (lipid mixing in the absence of viral content release) b...
Main Authors: | Tanay M Desai, Mariana Marin, Christopher R Chin, George Savidis, Abraham L Brass, Gregory B Melikyan |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-04-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC3974867?pdf=render |
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