Cisplatin Decreases ENaC Activity Contributing to Renal Salt Wasting Syndrome

Cisplatin Decreases ENaC Activity Contributing to Renal Salt Wasting Syndrome

Cisplatin (CDDP) is an important anticancer drug. A common side effect of CDDP is renal salt and water-wasting syndrome (RSWS). The origin of RSWS is obscure. Emerging evidence, though, suggests that broad inhibition of sodium transport proteins by CDDP may result in decreases in tubular reabsorptio...

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Bibliographic Details
Main Authors: Antonio G. Soares, Elena Mironova, Crystal R. Archer, Jorge Contreras, James D. Stockand, Tarek Mohamed Abd El-Aziz
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
Deg/ENaC channels
renal sodium excretion
hypertension
diuretic
pseduohypoaldosteronism
chemotherapy
Online Access:https://www.mdpi.com/2072-6694/12/8/2140

Internet

https://www.mdpi.com/2072-6694/12/8/2140

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