Cystatin C prevents neuronal loss and behavioral deficits via the endosomal pathway in a mouse model of down syndrome

Cystatin C prevents neuronal loss and behavioral deficits via the endosomal pathway in a mouse model of down syndrome

Cystatin C (CysC) plays diverse protective roles under conditions of neuronal challenge. We investigated whether CysC protects from trisomy-induced pathologies in a mouse model of Down syndrome (DS), the most common cause of developmental cognitive and behavioral impairments in humans. We have previ...

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Bibliographic Details
Main Authors: Gurjinder Kaur, Sebastien A. Gauthier, Rocio Perez-Gonzalez, Monika Pawlik, Amol Bikram Singh, Benjamin Cosby, Panaiyur S. Mohan, John F. Smiley, Efrat Levy
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Neurobiology of Disease
Subjects:
Cystatin C
Down syndrome
Spatial memory
Early endosome
Late endosome
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118305163

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http://www.sciencedirect.com/science/article/pii/S0969996118305163

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