Proteasomal degradation of p53 by human papillomavirus E6 oncoprotein relies on the structural integrity of p53 core domain.

Proteasomal degradation of p53 by human papillomavirus E6 oncoprotein relies on the structural integrity of p53 core domain.

The E6 oncoprotein produced by high-risk mucosal HPV stimulates ubiquitinylation and proteasome-dependent degradation of the tumour suppressor p53 via formation of a trimeric complex comprising E6, p53, and E6-AP. p53 is also degraded by its main cellular regulator MDM2. The main binding site of p53...

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Bibliographic Details
Main Authors: Xavier Bernard, Philip Robinson, Yves Nominé, Murielle Masson, Sebastian Charbonnier, Juan Ramon Ramirez-Ramos, Francois Deryckere, Gilles Travé, Georges Orfanoudakis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3203139?pdf=render

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http://europepmc.org/articles/PMC3203139?pdf=render

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