Chronic loss of STAG2 leads to altered chromatin structure contributing to de-regulated transcription in AML

Chronic loss of STAG2 leads to altered chromatin structure contributing to de-regulated transcription in AML

Abstract Background The cohesin complex plays a major role in folding the human genome into 3D structural domains. Mutations in members of the cohesin complex are known early drivers of myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML), with STAG2 the most frequently mutated complex...

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Bibliographic Details
Main Authors: James S. Smith, Katrina M. Lappin, Stephanie G. Craig, Fabio G. Liberante, Clare M. Crean, Simon S. McDade, Alexander Thompson, Ken I. Mills, Kienan I. Savage
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Journal of Translational Medicine
Subjects:
STAG2
Cohesion
Acute myeloid leukaemia
RNA-seq
ChIP-seq
HiChIP
Online Access:http://link.springer.com/article/10.1186/s12967-020-02500-y

Internet

http://link.springer.com/article/10.1186/s12967-020-02500-y

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