Gain of function in Mycobacterium bovis BCG Moreau due to loss of a transcriptional repressor

Gain of function in Mycobacterium bovis BCG Moreau due to loss of a transcriptional repressor

The Bacille Calmette-Guérin (BCG) vaccine comprises a family of genetically different strains derived by the loss of genomic regions (RDs) and other mutations. In BCG Moreau, loss of RD16 inactivates rv3405c * , encoding a transcriptional repressor that negatively regulates the expression of Rv3406...

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Bibliographic Details
Main Authors: Renata Monteiro-Maia, Paloma Rezende Correa, Periela da Silva Sousa-Vasconcelos, Rosa Teixeira de Pinho, Leila Mendonça-Lima
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2018-10-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
BCG Moreau
rv3405c
RV3406
THP-1 cells
tuberculosis
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018001100400&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018001100400&lng=en&tlng=en

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