Structural analysis of how podocytes detach from the glomerular basement membrane under hypertrophic stress

Structural analysis of how podocytes detach from the glomerular basement membrane under hypertrophic stress

Podocytes are lost by detachment from the GBM as viable cells; details are largely unknown. We studied this process in the rat after growth stimulation with FGF-2. Endothelial and mesangial cells responded by hyperplasia, podocytes underwent hypertrophy, but, in the long run, developed various chang...

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Bibliographic Details
Main Authors: Wilhelm eKriz, Brunhilde eHähnel, Hiltraud eHosser, Sigrid eRösener, Rüdiger eWaldherr
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Endocrinology
Subjects:
Podocyte hypertrophy
Foot process effacement
Sealing of filtration slits
Pseudocysts
Podocyte detachment
Crescents
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00207/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00207/full

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