Chronic ketamine reduces the peak frequency of gamma oscillations in mouse prefrontal cortex ex vivo

Abnormalities in EEG gamma band oscillations (GBO, 30-80 Hz) serve as a prominent biomarker of schizophrenia (Sz), associated with positive, negative and cognitive symptoms. Chronic, subanesthetic administration of antagonists of N-methyl-D-aspartate receptors (NMDAR), such as ketamine, elicits beha...

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Bibliographic Details
Main Authors: James M. McNally, Robert W. McCarley, Ritchie E. Brown
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Psychiatry
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00106/full