The Effects of WW2/WW3 Domains of Smurf2 Molecule on CD4+CD25+/CD4+ Proportion in Spleen of 4T1 Tumor Bearing BALB/c Mice
Background: TGF-β has long been considered as the main inducer of Tregs in tumor microenvironment and is the reason for the aberrant number of Tregs in tumor-bearing individuals. Recently, it has been suggested that the enzyme arginase I is able to mediate the induction of Tregs in a TGF-β-independe...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pasteur Institute of Iran
2020-07-01
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| Series: | Iranian Biomedical Journal |
| Subjects: | |
| Online Access: | http://ibj.pasteur.ac.ir/article-1-3041-en.html |