Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells

Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells

Abstract Metformin increased cellular ROS levels in AsPC-1 pancreatic cancer cells, with minimal effect in HDF, human primary dermal fibroblasts. Metformin reduced cellular ATP levels in HDF, but not in AsPC-1 cells. Metformin increased AMPK, p-AMPK (Thr172), FOXO3a, p-FOXO3a (Ser413), and MnSOD lev...

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Bibliographic Details
Main Authors: Madhuri Shende Warkad, Chea-Ha Kim, Beom-Goo Kang, Soo-Hyun Park, Jun-Sub Jung, Jing-Hui Feng, Gozde Inci, Sung-Chan Kim, Hong-Won Suh, Soon Sung Lim, Jae-Yong Lee
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-93270-0

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https://doi.org/10.1038/s41598-021-93270-0

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