Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs

<p>Abstract</p> <p>Background</p> <p>Curcumin inhibits growth of several cancer cell lines, and studies in this laboratory in bladder and pancreatic cancer cells show that curcumin downregulates specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and pro-onc...

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Bibliographic Details
Main Authors: Gandhy Shruti U, Kim KyoungHyun, Larsen Lesley, Rosengren Rhonda J, Safe Stephen
Format: Article
Language:English
Published: BMC 2012-11-01
Series:BMC Cancer
Subjects:
Online Access:http://www.biomedcentral.com/1471-2407/12/564