Chrysosplenetin inhibits artemisinin efflux in P-gp-over-expressing Caco-2 cells and reverses P-gp/MDR1 mRNA up-regulated expression induced by artemisinin in mouse small intestine

Chrysosplenetin inhibits artemisinin efflux in P-gp-over-expressing Caco-2 cells and reverses P-gp/MDR1 mRNA up-regulated expression induced by artemisinin in mouse small intestine

Context: CYP3A4 and P-gp together form a highly efficient barrier for orally absorbed drugs and always share the same substrates. Our previous work revealed that chrysosplenetin (CHR) significantly augmented the rat plasma level and anti-malarial efficacy of artemisinin (ART), partially due to the u...

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Bibliographic Details
Main Authors: Liping Ma, Shijie Wei, Bei Yang, Wei Ma, Xiuli Wu, Hongyan Ji, Hong Sui, Jing Chen
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Pharmaceutical Biology
Subjects:
polymethoxylated flavonoids
antimalarial drugs
abc transporters
p-glycoprotein
Online Access:http://dx.doi.org/10.1080/13880209.2016.1241810

Internet

http://dx.doi.org/10.1080/13880209.2016.1241810

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