Burn-Induced Cardiac Mitochondrial Dysfunction via Interruption of the PDE5A-cGMP-PKG Pathway

Burn-Induced Cardiac Mitochondrial Dysfunction via Interruption of the PDE5A-cGMP-PKG Pathway

Burn-induced heart dysfunction is a key factor for patient mortality. However, the molecular mechanisms are not yet fully elucidated. This study sought to understand whether burn-induced heart dysfunction is associated with cardiac mitochondrial dysfunction and interruption of the PDE5A-cGMP-PKG pat...

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Bibliographic Details
Main Authors: Jake J. Wen, Claire B. Cummins, Ravi S. Radhakrishnan
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
burn injury
mitochondria
oxygen consumption
electron transport chain
sildenafil
Online Access:https://www.mdpi.com/1422-0067/21/7/2350

Internet

https://www.mdpi.com/1422-0067/21/7/2350

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