Deletion of FUNDC2 and CMC4 on Chromosome Xq28 Is Sufficient to Cause Hypergonadotropic Hypogonadism in Men

Deletion of FUNDC2 and CMC4 on Chromosome Xq28 Is Sufficient to Cause Hypergonadotropic Hypogonadism in Men

BackgroundHypergonadotropic hypogonadism (HH) is characterized by low sex steroid levels and secondarily elevated gonadotropin levels with either congenital or acquired etiology. Genetic factors leading to HH have yet to be fully elucidated.MethodsHere, we report on genome and transcriptome data ana...

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Bibliographic Details
Main Authors: Xinxian Deng, He Fang, Asha Pathak, Angela M. Zou, Whitney Neufeld-Kaiser, Emily A. Malouf, Richard A. Failor, Fuki M. Hisama, Yajuan J. Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Genetics
Subjects:
CMC4
FUNDC2
hypergonadotropic hypogonadism
Sertoli cell barrier
apoptosis
Xq28 deletion
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.557341/full

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https://www.frontiersin.org/article/10.3389/fgene.2020.557341/full

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