PDE3 Inhibition Reduces Epithelial Mast Cell Numbers in Allergic Airway Inflammation and Attenuates Degranulation of Basophils and Mast Cells

PDE3 Inhibition Reduces Epithelial Mast Cell Numbers in Allergic Airway Inflammation and Attenuates Degranulation of Basophils and Mast Cells

Epithelial mast cells are generally present in the airways of patients with allergic asthma that are inadequately controlled. Airway mast cells (MCs) are critically involved in allergic airway inflammation and contribute directly to the main symptoms of allergic patients. Phosphodiesterase 3 (PDE3)...

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Bibliographic Details
Main Authors: Jan Beute, Keerthana Ganesh, Hedwika Nastiti, Robin Hoogenboom, Vivica Bos, Jelle Folkerts, Marco W. J. Schreurs, Steve Hockman, Rudi W. Hendriks, Alex KleinJan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
allergic airway
animal model
asthma
enoximone
house dust mite
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00470/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00470/full

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